PLATINUM is designed for calculation of hydrophobic properties of molecules and their match or mismatch in receptor–ligand complexes. These properties may help to analyze results of molecular docking.

Step 1: Upload files

Please select a ’ligand“ file (in one-by-one mode) — if you want just to assess their hydrophobic properties — and add a single receptor file to assess ligand/receptor interactions. (File size limit: 5 Mb.)

Select a receptor file:

Select file(s) with ligands:

Please note: PLATINUM requires that all molecules are protonated!


Calculate and visualize molecular hydrophobic/hydrophilic properties using the concept of “Molecular Hydrophobicity Potential” (MHP). Hydrophobic and stacking interactions in biomolecular complexes can be estimated and used to re-rank the results of molecular docking. For certain cases — lipid bilayers and α-helices — 2D hydrophobicity maps can be calculated.

How to use PLATINUM?

  • Complementarity of hydrophobic/hydrophilic properties in biomolecular complexes:
    • to view molecular hydrophobic properties upload ligand(s);
    • to view hydrophobic complementarity add a receptor;
    • on Step 2 select a reference ligand (optionally).
  • 2D hydrophobic maps for lipid bilayers and α-helices:
    • upload a bilayer or an α-helix as a receptor (currently only.GRO files are allowed);
    • add ligand(s) to view the contact area on the map (optionally).

For details refer to the manual and go through the tutorial; don’t forget files for the tutorial.

System requirements

Some components on the site (viz. massive files upload) require modern web-browser with javascripts enabled and Flash-9 plugin installed. You’ll also need Java to see visualization online.